The knowledge of medicine underwent a revolution in the Qajar period, especially during the reign of Naser al-Din Shah Qajar (1831-1896 AD). The dispatch of students to Europe, establishment of Dar ul-Funun, Hafez al-Seheh Assembly, and clinics, entrance of European teachers and physicians to Iran, approval of medical rules by the parliament, introduction of a new therapeutic style, and translation of medical textbooks into Persian were some of the changes that occurred during this period. As a result, modern medicine influenced the Iranian-Islamic traditional medicine. An educated Iranian physician, Mirza Ali Doctor Hamedani was one of the physicians of this period, who traveled to France, studied the European medicine and considerably contributed to the evolution of the modern medicine along the traditional medicine. The present manuscript describes the scientific personality and contributions of this physician to the science of medicine.