Study of biopsy material obtained from 612 surgical patients with vertebrogenic diseases of spinal radicles at the lumbosacral level and collation of the morphologic findings with the clinical picture of the disease revealed a correlation between the clinical manifestations and the inflammatory process in the vascularized tissues of the vertebral column. The severity of pain was found to depend on the degree of inflammatory changes in the epidural cellular tissue and spinal membranes. The frequency and severity of inflammatory reactions make it possible to consider inflammation, along with compression and ischemia, an important pathogenetic mechanism of the development, progression and course of the discogenic radicular syndrome and to recommend the inclusion of antiinflammatory drugs in multiple modality treatment of the disease as a method of pathogenetic therapy.