To study the chemical constituents of Securidaca inappendiculata.The chemical constituents were isolated and purified by chromatography on silica gel, Sephadex LH-20 columns. Their structures were elucidated by means of physicochemical properties and spectroscopic analysis.Ten compounds were identified from the dichloromethane fraction of Securidaca inappendiculata, and identified as 1,7-dihydroxyxanthone (1), 1,3,8-trihydroxy-2-methoxyxanthone (2), 1,7-dihydroxy-3,4-dimethoxyxanthone (3), 1,3,8-trihydroxy-4-methoxyxanthone (4), 7-hydroxy-1,2-dimethoxyxanthone (5), 1,3,6-trihydroxy-2,7-dimethoxyxanthone (6), 1,4, 8-trihydroxyxanthone (7), 1,7-dihydroxy-3-methoxyxanthone (8), 1,6-dihydroxy-7-methoxyxanthone (9) and 1,8-dihydroxy-3,4-dimethoxyxanthone (10).Compounds 7–10 are isolated from this plant for the first time, and compounds 7–10 are isolated from this genus for the first time.