
Poly(adenosine 5'-diphosphate ribose) [poly(ADP-ribose]) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide, especially in 0.5 M NaCl and at an alkaline pH. The ADP-ribose residues are monomeric and are attached to the middle of polymer chains. The linkage is similar to, and may be identical with, that of the branch points that are created in cells. RNA is also spontaneously ADP-ribosylated, but not DNA.
Poly Adenosine Diphosphate Ribose, Nucleoside Diphosphate Sugars, Swine, Brain, RNA, Fungal, Hydrogen-Ion Concentration, NAD, Kinetics, Structure-Activity Relationship, NAD+ Nucleosidase, Animals, Phosphorus Radioisotopes, Plasmids
Poly Adenosine Diphosphate Ribose, Nucleoside Diphosphate Sugars, Swine, Brain, RNA, Fungal, Hydrogen-Ion Concentration, NAD, Kinetics, Structure-Activity Relationship, NAD+ Nucleosidase, Animals, Phosphorus Radioisotopes, Plasmids
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