[Specific binding of 3H-naloxone with isolated rat enterocytes].

K N, Iarygin; D D, Sviridov; A G, Shitin; V A, Vinogradov; M I, Titov

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Bulletin of Experimental Biology and Medicine

Article . 1985

Data sources: Europe PubMed Central

[Specific binding of 3H-naloxone with isolated rat enterocytes].

descriptionPublicationkeyboard_double_arrow_right Article 23 Sep 1985 Russian Journal:Biulleten' eksperimental'noi biologii i meditsiny, volume 100 (issn: 0365-9615,

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Authors: K N, Iarygin; D D, Sviridov; A G, Shitin; V A, Vinogradov; M I, Titov;

pmid: 2990595

[Specific binding of 3H-naloxone with isolated rat enterocytes].

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Abstract

Specific 3H-naloxone binding with isolated rat enterocytes has been demonstrated. This binding was selectively inhibited by different opiates and proved to be irreversible, temperature-dependent and sodium azide-sensitive. The presence of naloxone binding sites on enterocytes indicates a possible involvement of opiates in the regulation of enterocyte functions.

Keywords

Male, Narcotics, Dose-Response Relationship, Drug, Naloxone, In Vitro Techniques, Ligands, Tritium, Rats, Kinetics, Intestine, Small, Receptors, Opioid, Animals

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