Molecular epidemiology of two US orbiviruses: bluetongue virus and epizootic hemorrhagic disease virus.

P, Roy; K, Sugiyama; C D, Rao; J, Kusari; M, Purdy; E, Collisson

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Article . 1985

Data sources: Europe PubMed Central

Molecular epidemiology of two US orbiviruses: bluetongue virus and epizootic hemorrhagic disease virus.

descriptionPublicationkeyboard_double_arrow_right Article 07 Aug 1985 English Journal:Progress in clinical and biological research, volume 178 (issn: 0361-7742,

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Authors: P, Roy; K, Sugiyama; C D, Rao; J, Kusari; M, Purdy; E, Collisson;

pmid: 2989908

Molecular epidemiology of two US orbiviruses: bluetongue virus and epizootic hemorrhagic disease virus.

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Abstract

The degree of relatedness between 4 US serotypes (10, 11, 13 and 17) of bluetongue (BT) virus (BTV) were determined by both oligonucleotide fingerprint analyses of double-stranded (ds) RNA as well as tryptic peptide analyses of viral coded polypeptides. Similar studies were undertaken using different alternate isolates of particular serotypes as well as 2 serotypes (1 and 2) of epizootic hemorrhagic disease (EHD) virus (EHDV), a closely related serogroup of orbiviruses. The results indicate that all BT viruses are genetically related to each other and although EHDV-1 and EHDV-2 originated from a common gene pool, the 2 serogroups, EHDV and BTV, are not genetically interactive.

Keywords

Oligoribonucleotides, Reoviridae, Peptide Fragments, United States, Molecular Weight, Viral Proteins, Species Specificity, RNA, Viral, Serotyping, Bluetongue virus, RNA, Double-Stranded

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