Extraction is one of the more common oral surgical procedures carried out in routine dental practice, and postextraction bleeding is a recognized, frequently encountered complication. It causes distress, agony, and discomfort to the patient. The aim of this systematic review was to analyze the existing literature and determine the efficacy of topical hemocoagulase as a hemostatic agent and its ability to reduce postoperative complications in comparison to routine saline pressure pack after the extraction of teeth. Information was collected from an electronic database (PubMed), and a manual search was also done in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology; International Journal of Oral and Maxillofacial Surgery; and the British Journal of Oral and Maxillofacial Surgery. Only those articles which met the inclusion criteria were selected. All studies and articles that compared topical hemocoagulase with saline pressure pack in patients requiring extraction of teeth were selected for review. Literature abstracts and full-text articles were analysed in this review. A total of four articles were included in this systematic review. All were randomized clinical trials that evaluated the clinical outcomes of topical hemocoagulase compared with saline pressure packs in extraction socket sites. A significant difference was present between the hemocoagulase group and control group (saline pressure pack) in relation to bleeding stoppage time, pain, swelling, wound healing, and other postoperative complications. Topical hemocoagulase is significantly effective in reducing bleeding, pain, and swelling after extraction of tooth when compared to saline pressure packs. It also acts as a promoter of wound healing.