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Rate constants of absorption versus physico-chemical parameters.

Authors: T, Past; Z, Tapsonyi; L, Nagy; T, Jávor;

pmid: 29840

Rate constants of absorption versus physico-chemical parameters.

Abstract

We examined the velocity constants of buccal absorption in the case of 10 drugs. The measurements tending towards what is the coherence between the velocity constants and the physico-chemical parameters of the drugs. On the basis of our investigations one can see that the dipol moment offers more reliable information for the size of the velocity of absorption than the lipid-water distribution ratio, molecular radii or diffusion constants. Our opinion is that it can be useful in modifying and planning the drug molecules.

Keywords

Diffusion, Kinetics, Cheek, Chemical Phenomena, Pharmaceutical Preparations, Solubility, Chemistry, Physical, Mouth Mucosa, Hydrogen-Ion Concentration, Absorption

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Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
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