Perineo-gluteal hidradenitis suppurativa, or Verneuil's disease, consists of infected and more or less fistulized lesions unconnected with the anal canal, dermo-epidermal nodule and diffuse subcutaneous infiltration. The disease is chronic with acute episodes and periods of stabilization and it interferes with the patient's daily life. The lesions originate in the apocrine sweat glands which are predominantly located in the inguinal, perineal and gluteal regions but may also be found in the axillary, areolar and periumbilical regions. The cause of the disease is unknown, but it has been attributed to an anaerobic Streptococcus, to hormonal factors or to maceration or dysembryoplasia. Treatment consists of wide excision of the lesions followed by a network of skin grafts after a granulation period. Isotretinoin has not yet been proved effective.