[Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer].
Copyright policy )[Relationships between the enrichment of ETBF, Fn, Hp in intestinal and colorectal cancer].
Objective: To explore relationships between the enrichment of ETBF, Fn, Hp in feces, tissues and colorectal cancer. Methods: Feces, lesion tissue and adjacent tissue from 24 patients with colorectal cancer and 31 patients with adenomas were collected, and we collected Feces and tissue of 20 healthy control persons. Then the copy numbers of enterotoxigenic B. fragilis (ETBF), Fusobacterium nucleatum (Fn) and Helicobacter pylori (Hp) were determined by quantitative real-time PCR. Immunohistochemical method was used to examine the expression intensity of EGFR and p53, and the relationships between different expression intensity of EGFR, p53 and the numbers of three bacterias. Results: In the feces, copy numbers of ETBF and Fn were as follous: colorectal cancer group>adenomas group>healthy control group (Phealthy control group (Phealthy control group (Padenomas group>healthy control group (Phealthy control group (Phealthy control group (P0.05). Conclusion: Adenomatous polyp and colorectal cancer patients show high enrichment of ETBF, Fn and Hp in both feces and tissues. ETBF, Fn and Hp probably contribute to the development of adenomatous polyp and colorectal cancer. Trial registration Chinese Clinical Trial Registry, ChiCTR-BOC-17012509.
- Second Affiliated Hospital of Xi'an Jiaotong University China (People's Republic of)
Adenoma, Bacteroides fragilis, Feces, Fusobacterium nucleatum, Helicobacter pylori, Case-Control Studies, Humans, Colorectal Neoplasms, Real-Time Polymerase Chain Reaction
Adenoma, Bacteroides fragilis, Feces, Fusobacterium nucleatum, Helicobacter pylori, Case-Control Studies, Humans, Colorectal Neoplasms, Real-Time Polymerase Chain Reaction
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