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Surveillance of variant mecA gene and analysis of efflux pump in mecA negative MRSA infections.

Authors: Karthikeyan, Vijayan; Sulochana, Somasundaram; Catherine, Leo; Jayaprakash, Kanagaraj;

Surveillance of variant mecA gene and analysis of efflux pump in mecA negative MRSA infections.

Abstract

It has been known from the medical records of Kancheepuram district hospitals that there is a prevalence of Methicillin resistant Staphylococcus aureus strain. Now the recent epidemiology has shown the presence of Methicillin Resistant Staphylococcus aureus even in school going children community individuals. In view of the above situation, Methicillin resistant Staphylococcus aureus screening was undertaken in the above said region. Both samples from hospital sources and school going children were screened for Methicillin Resistant Staphylococcus aureus. The results have shown that the samples had multiantibiotic resistant property along with methicillin resistance. The genomic studies have revealed that there were of positive genomic sequence for mec A and 5 isolates for mecA negative gene sequence. This would assume that even negative mec A genome has the resistant expression. Out of the 5 isolates two isolates have shown the presence of both nor A and qac A/B genes. The above results are discussed with efflux of drugs and future proposal on proteomics.

Keywords

Male, Methicillin-Resistant Staphylococcus aureus, ATP-Binding Cassette, Sub-Family C Proteins, Molecular Epidemiology, Adolescent, Genotype, India, Membrane Transport Proteins, Microbial Sensitivity Tests, Staphylococcal Infections, Anti-Bacterial Agents, Phenotype, Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Humans, Penicillin-Binding Proteins, Female, Methicillin Resistance, Child

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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