Evaluation of the sterility of single-dose medications used in a multiple-dose fashion.
Copyright policy )Evaluation of the sterility of single-dose medications used in a multiple-dose fashion.
Bacterial proliferation was evaluated in single-dose medications used in a multi-dose fashion and when medications were intentionally inoculated with bacteria. Of 5 experimentally punctured medications, 1 of 75 vials (50% dextrose) became contaminated. When intentionally inoculated, hydroxyethyl starch and heparinized saline supported microbial growth. Based on these findings, it is recommended that hydroxyethyl starch and heparinized saline not be used in a multi-dose fashion.
- Animal Medical Center United States
- Tufts University United States
- Murdoch University Australia
Dosage Forms, Staphylococcus aureus, Pseudomonas aeruginosa, Animals, Veterinary Drugs, Infusions, Parenteral, Drug Contamination, Drug Packaging
Dosage Forms, Staphylococcus aureus, Pseudomonas aeruginosa, Animals, Veterinary Drugs, Infusions, Parenteral, Drug Contamination, Drug Packaging
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