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Streptococcus agalactiae: prevention and vaccine development.

Authors: Puertas-Prieto, A.; Lara-Oya, A.; Liébana Martos, C.; Rodríguez-Granger, J.; Cobo, F.; Sampedro, A.; Padilla, A.; +5 Authors

Streptococcus agalactiae: prevention and vaccine development.

Abstract

Streptococcus agalactiae, estreptococo del grupo B (EGB), es la mayor causa de morbi-mortalidad entre los neonatos y un patógeno importante entre los pacientes adultos inmuno deprimidos. A pesar de los avances en la prevención y trata miento de la infección neonatal, fruto de la implantación de las recomendaciones nacionales e internacionales que en las últimas dos décadas se han desarrollado para ello, aún quedan pendientes mejoras para el control definitivo de la enferme dad. En este sentido, la vacunación frente a EGB podría ser una medida eficaz para la prevención de la infección en aquellos casos donde la profilaxis intraparto no es útil y en pacientes adultos con factores de riesgo de desarrollar infección invasi va por EGB. Esta revisión resume los esfuerzos llevados a cabo para controlar esta infección y aporta información sobre el es tado actual de las vacunas frente a EGB empleando diferentes estrategias en su diseño

Streptococcus agalactiae, group B Streptococcus (SGB), is the most important cause of morbi-mortality among newborn population, and an important pathogen among immunossupressed adult patients. Despite the advances in the treatment and prevention of neonatal infections as a consequence of implementation of national and international recommendations for prevention of infection, there are still some improvements for the final control of the disease. In this sense, the vaccination against SGB could be an effective measure for the prevention of disease in those cases where intrapartum prophylaxis is not useful and in adult patients with risk factors for invasive infection due to SGB. This review summarizes the efforts made until now in order to establish the control of the infection, and brings some information on the current state-of-the art of vaccines against SGB, in which different strategies in their design have been used.

Keywords

Vaccines, Conjugate, Vaccination, Infant, Newborn, Streptococcus agalactiae, embarazo, vacuna, conjugada, polisacárido, Infant, Newborn, Diseases, Streptococcus agalactiae, Pregnancy, Streptococcal Infections, Bacterial Vaccines, Streptococcus agalactiae, pregnancy, vaccine, conjugated, polysaccharide, Humans, Female, Pregnancy Complications, Infectious

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
Green
gold