The coding sequence for the 32,000-dalton pulmonary surfactant-associated protein A is located on chromosome 10 and identifies two separate restriction-fragment-length polymorphisms.
Copyright policy )The coding sequence for the 32,000-dalton pulmonary surfactant-associated protein A is located on chromosome 10 and identifies two separate restriction-fragment-length polymorphisms.
The primary protein component of human pulmonary surfactant is a 32,000-dalton glycoprotein called surfactant-associated protein A. This protein is important for normal lung function, and its expression is developmentally regulated. Using a mapping panel of somatic-cell hybrids, we have localized the coding sequence for pulmonary surfactant-associated protein A to chromosome 10. Additionally, this sequence identifies two separate MspI restriction-fragment-length polymorphisms. Since there is a relative lack of polymorphic markers for chromosome 10, this sequence may be useful in linkage analysis.
Genetic Markers, Polymorphism, Genetic, Pulmonary Surfactant-Associated Proteins, Base Sequence, Chromosomes, Human, Pair 10, Genetic Linkage, Proteolipids, Chromosome Mapping, Pulmonary Surfactants, DNA, Hybrid Cells, Cricetulus, Cricetinae, Animals, Humans, Polymorphism, Restriction Fragment Length
Genetic Markers, Polymorphism, Genetic, Pulmonary Surfactant-Associated Proteins, Base Sequence, Chromosomes, Human, Pair 10, Genetic Linkage, Proteolipids, Chromosome Mapping, Pulmonary Surfactants, DNA, Hybrid Cells, Cricetulus, Cricetinae, Animals, Humans, Polymorphism, Restriction Fragment Length
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