The prevalence and intensity of endo and ectoparasites in shrews inhabiting in the Dasht-e Razan of Hamedan Province, Iran, were determined in this study.By live traps, 64 shrews belong to species bicoloured white-toothed shrews (Crocidura leucodon) were trapped during 2010-2012. Captured animals were euthanized and their gender recorded. The blood thick and thin smears were stained with Geimsa and examined for protozoan parasites. Then, ectoparasites were collected and preserved in 70% ethanol and after necropsies; different organs were examined for helminthes.The prevalence of collected helminthes of Crocidura leucodon were; Capillaria crociduri (18.7%), Vigisolepis secunda (26.5%), Coronacantus sp (15.6%), Capillaria hokkaidensis (45.3%), and its ectoparasites were; Nymphs of three species of ticks; Haemaphysalis sp (32.8%), Ornitodoros sp (23.4%), Hyalomma sp (9.4%), one species of louse, Polyplax reclinata (18.7%) and one species of flea Leptopsylla sp (39.1%). Among the collected parasites, all helminthes and one sucking louse, P. reclinata are reported for the first time in Iran. Statistically analysis with the Chi-square test did not show any significant relation between gender and endoparasites (P>0.05), but the ectoparasites had significant differences with gender (P0.05).This study reports 9 species of parasites and 5 species of them were identified for the first time in Iran and some of them are vectors of several important zoonoses agents.