[Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].

V I, Kulinskiĭ; I A, Ol'khovskiĭ; A N, Kovalevskiĭ

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Bulletin of Experimental Biology and Medicine

Article . 1986

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[Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].

descriptionPublicationkeyboard_double_arrow_right Article 17 Sep 1986 Russian Journal:Biulleten' eksperimental'noi biologii i meditsiny, volume 101 (issn: 0365-9615,

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Authors: V I, Kulinskiĭ; I A, Ol'khovskiĭ; A N, Kovalevskiĭ;

pmid: 2873847

[Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia].

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Abstract

The antihypoxic effect of alpha 2-adrenoceptor agonists was studied by two different approaches: reproduction of the effect by a number of alpha 2-agonists and its blockade with selective antagonists. The data obtained suggest that alpha 2-adrenoceptor agonists increase the survival and the lifespan of mice in all the models of acute hypoxic hypoxia under study. A close correlation between antihypoxic action of alpha 2-adrenoceptor agonists and their anticalorigenic effect was established (r = +0.87; P less than 0.01).

Keywords

Mice, Oxygen Consumption, Animals, Female, Receptors, Adrenergic, alpha, Hypoxia, Adrenergic alpha-Agonists

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