The most significant chronic non-infectious diseases (CVD) are cardiovascular diseases (CVD), oncological, chronic respiratory diseases, diabetes, which together account for 59% of 57 million deaths each year in the world and constitute 46% of the global burden of the disease.To study the contribution of cardiovascular diseases to the overall mortality of the population of the Poltava region.For the study, the mortality data of the population of Ukraine and the Poltava region for 2005-2015 were used. Sources of data on the natural movement of the population were forms of state statistical reporting and official data on calculations for primary data of statistical offices. The calculation of intensive death rates by the method of direct standardization according to the world standard (Standard "World"), approved by WHO [19] was carried out. For the analysis of time trends, the JoinPoint software, the Regression Program Statistical Methodology and Applications Branch, the Surveillance Research Program (Electronic Resourse) / National Cancer Institute, was used to analyze population-based piece-wise time trends, as well as the MS EXCEL 2010 office suite.It was shown the increase in the overall mortality of the population of the Poltava region and Ukraine as a whole. In the structure of the causes of death, the first place is occupied by diseases of the cardiovascular system, and in the structure of the Diseases of the blood supply systems, the greatest part is occupied by ischemic heart disease. An increase in mortality and mortality from acute myocardial infarction was noted.The contribution of diseases of the cardiovascular system plays a leading role among all causes of mortality in the Poltava region and in Ukraine as a whole. There is an increase in overall mortality and in particular from acute myocardial infarction. A significant difference between mortality rates, both general and from myocardial infarction, in Ukraine and the Poltava region was not revealed (p> 0.05).