Post-operative pain is a problem for many patients and affects recovery, risk of post-operative complications and quality of life. A thorough preoperative evaluation, careful perioperative planning, identification, and individualized treatment of high-risk patients can reduce post-operative pain. Multimodal treatment combines different analgesic techniques in order to utilize synergistic and additive effects of different treatments and has the potential to optimize effects and reduce side effects. Identification and treatment of patients with chronic post-operative pain should be prioritized.