Urokinase Plasminogen Activator Receptor-PET with 68Ga-NOTA-AE105: First Clinical Experience with a Novel PET Ligand.
Copyright policy )Urokinase Plasminogen Activator Receptor-PET with 68Ga-NOTA-AE105: First Clinical Experience with a Novel PET Ligand.
Urokinase plasminogen activator receptor (uPAR) is a key component in proteolysis and extracellular matrix degradation during cancer invasion and metastasis. uPAR overexpression is an important biomarker for aggressiveness in several solid tumors and provides independent clinical information. A recent major breakthrough was obtained with human translation of uPAR PET using 68Ga-NOTA-AE105. Clinical results are encouraging and several large-scale clinical trials are now ongoing. This review focuses on uPAR PET with 68Ga-NOTA-AE105 as a new broadly applicable diagnostic and prognostic imaging biomarker in cancer.
- University of Copenhagen Denmark
- University of Copenhagen Denmark
- IT University of Copenhagen Denmark
Prostate cancer, Molecular imaging, Gallium Radioisotopes, Prognostication, Theranostics, Ligands, Invasiveness, Receptors, Urokinase Plasminogen Activator, Breast cancer, PET, Oncology, Neoplasms, Positron-Emission Tomography, Humans, Radiopharmaceuticals, Radionuclide Imaging, Tomography, X-Ray Computed
Prostate cancer, Molecular imaging, Gallium Radioisotopes, Prognostication, Theranostics, Ligands, Invasiveness, Receptors, Urokinase Plasminogen Activator, Breast cancer, PET, Oncology, Neoplasms, Positron-Emission Tomography, Humans, Radiopharmaceuticals, Radionuclide Imaging, Tomography, X-Ray Computed
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