Viral hepatitis: The bumpy road to animal models for HBV infection.

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2017 Germany English Publisher:Nature Publishing GroupJournal:Nature reviews. Gastroenterology & hepatology, volume 14 (issn: 1759-5053,

Copyright policy )Funded by:EC | HEP-CAR

Authors: Ulrike Protzer;

pmid: 28400622

Viral hepatitis: The bumpy road to animal models for HBV infection.

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Abstract

Cell culture infection models help to develop antiviral agents, but animal models are required to understand complex virus-host interactions and the development of immune therapies. Although identification of the HBV uptake receptor enabled establishing cell lines that replicate HBV from its natural transcription template, animal models supporting the full HBV life cycle are still lacking.

Country

Germany

Related Organizations

Technical University of Munich
Germany
Helmholtz Zentrum München
Germany

Keywords

Hepatitis B virus, Symporters, Swine, Models, Animal, Hepatocytes, Animals, Macaca, Organic Anion Transporters, Sodium-Dependent, Hepatitis B

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