A cDNA for the gene that encodes for a human cellular thyroid hormone-binding protein (p55) has recently been isolated and sequenced. The sequence of p55 indicates that it is identical to the protein disulfide isomerase and the beta-subunit of prolyl 4-hydroxylase. By in situ hybridization, the gene for p55 was localized on chromosome 17 at band q25. This localization shows that the p55 gene is not linked to either erbA1 or erbA2; two other thyroid hormone-binding protein genes are located at 17q 11-21 and 3p21-pter, respectively. The localization of p55 gene will permit the evaluation of the possible effects of chromosome changes on the structure and activity of the p55 gene in chromosome syndromes or neoplasms.

Related Organizations

National Cancer Institute
United States

Keywords

Thyroid Hormones, Procollagen-Proline Dioxygenase, Protein Disulfide-Isomerases, Chromosome Mapping, Membrane Proteins, Nucleic Acid Hybridization, Genes, Karyotyping, Humans, Lymphocytes, Carrier Proteins, Isomerases, Cells, Cultured, Metaphase, Chromosomes, Human, Pair 17, Thyroid Hormone-Binding Proteins

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