Two patients with multiple, metastatic nodules in the skin are described. One of them was a 52-year old man who had midtarsal amputation of his right foot for 'melanoma' of the s6le. The other was a female patient who presented with multiple cutaneous nodules, which on histology proved to be undifferentiated carcinoma cell deposits. The primary site of carcinoma was not detected in this case. Both patients developed leukoderma around the metastatic nodules. Peritumoural leukoderma was followed by the spontaneous regression of two metastatic nodules in the latter case. The possible mechanism is discussed with a review of the literature.