The significant role of house dust mites responsible for health hazards such as respiratory allergy, nasobronchial, and nasal allergy in sensitive individual is well documented. Critical investigations, however, of house dust mite allergy in the tropics are few. The present investigations have helped in locating the source, assessment, quantitative and qualitative estimation, seasonal variations, and effect of meteorologic variables on house dust mite allergy and its relevance to clinical data of patients.