The 2009 influenza A - subtype H1N1 pandemic tested the public health care systems all around the globe, infecting millions and leading to thousands of deaths. Greece became the epidemic centre of the 2009 flu pandemic due to the low compliance of the general population towards the vaccination programme, the resistance acquired against antiviral drugs and the economic scenario at the time. Our study, after a thorough research in the "Medline/PubMed, Scopus, Google Scholars" medical databases, accompanied by a wide range search of medical literature from Greece, sought to have a closer look at the pandemic from a Greek perspective. Finally, we used as key words the terms: "2009, flu, influenza A - H1N1 virus, vaccine, pandemic, Greece".