Pasteurella multocida, a Gram-negative facultative anaerobic coccobacillus, is a common oral flora of dogs and cats. P. multocida often causes infection in humans after animal bites and scratches, and human pasteurellosis is generally a locoregional infection. Systemic complications, particularly endocarditis, are very rare, except in immunodeficient patients. Endocarditis caused by P. multocida can have severe outcomes; hence, surgical treatment is often required. Here, a case is described of endocarditis caused by P. multocida in a previously healthy patient with no history of animal injury, which was successfully treated with surgery.