Endoscopic retrograde cholecystocholangiopancreatography and subsequent manometry in 1,018 patients with diseases of the biliary tract showed signs of stenosis of the major duodenal stenosis in the absence of concrements in the biliary system in 25 (2.45%) of them. On the basis of the results of such examination and the clinical and laboratory findings, the authors suggest that patients with benign stenosis of the major duodenal papilla should be divided into two groups: Group 1, with compensated stenosis and Group 2, with decompensated stenosis of the major duodenal papilla. Depending on the degree of the stenosis, they suggest the following endoscopic organ-preserving surgical interventions: endoscopic papillomyotomy and sparing endoscopic papillosphincterotomy.