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</script>Carpal tunnel syndrome is a neuropathy caused by compression of the median nerve within the carpal tunnel. However, the severity of symptoms and signs does not often correlate well with the extent of nerve damage.We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of drug treatments, non-drug treatments, surgical treatments, and postoperative treatments for carpal tunnel syndrome? We searched: Medline, Embase, The Cochrane Library and other important databases up to December 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).We found 54 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.In this systematic review we present information relating to the effectiveness and safety of the following interventions: acupuncture; diuretics; carpal tunnel release surgery (open, and endoscopic); internal neurolysis; local and systemic corticosteroids; massage therapy; nerve and tendon gliding exercises; non-steroidal anti-inflammatory drugs; pyridoxine; therapeutic ultrasound; and wrist splints.
Male, Ultrasonic Therapy, Administration, Oral, Neurosurgical Procedures, Injections, Age Distribution, Adrenal Cortex Hormones, Prevalence, Humans, Sex Distribution, Aged, Incidence, Anti-Inflammatory Agents, Non-Steroidal, Endoscopy, Middle Aged, Prognosis, Carpal Tunnel Syndrome, United States, Exercise Therapy, Splints, Surgical Procedures, Operative, Female, Safety
Male, Ultrasonic Therapy, Administration, Oral, Neurosurgical Procedures, Injections, Age Distribution, Adrenal Cortex Hormones, Prevalence, Humans, Sex Distribution, Aged, Incidence, Anti-Inflammatory Agents, Non-Steroidal, Endoscopy, Middle Aged, Prognosis, Carpal Tunnel Syndrome, United States, Exercise Therapy, Splints, Surgical Procedures, Operative, Female, Safety
| citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 21 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
