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Nature Chemical Biology
Article . 2017
Data sources: Europe PubMed Central
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Target validation: Switching domains.

descriptionPublicationkeyboard_double_arrow_right Article 27 Dec 2017 United Kingdom English Journal:Nature chemical biology, volume 12 (issn: 1552-4469, Copyright policy )
Authors: Ciulli, Alessio;

pmid: 27538023

Target validation: Switching domains.

Abstract

Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.

Country
United Kingdom
Related Organizations
Keywords

570, Cancer therapy, Small molecules, 610, Transcription, Chemical genetics, Target validation

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities
UArctic
Cancer Research