
pmid: 27537718
handle: 11468/22893
rdiogram (ECG), can be used as a marker of transmural dispersion of repolarization. Also, Tp-e/QT and Tp-e/QTc ratios are used as an index of arrhythmogenesis. Prolonged Tp-e interval and Tp-e/QT ratio was found associated with sudden cardiac death in different clinical conditions. Novel ventricular repolarization parameters, Tp-e interval, Tp-e/QT and Tp-e/QTc ratios have not been evaluated in patients with sarcoidosis without cardiac symptoms previously.Therefore, we investigated Tp-e interval in patients with pulmonary sarcoidosis.Sixty-one consecutive patients diagnosed with biopsy-proven pulmonary sarcoidosis were retrospectively reviewed. The 12-lead ECG examinations were performed at speed of 25 mm/s while the patients were in supine position. QT dispersion, Tp-e intervals and Tp-e/QT ratio were measured.Comparison of ECG parameters between two groups showed a significantly higher average heart rate (p< 0.05) in the patients with sarcoidosis than controls. QT dispersion was higher in patients group. Tp-e interval was significantly prolonged in the study group compared to the control group (92±21 ms and 85±14 ms, respectively; p< 0.05). Tp-e/QT and Tp-e/QTc ratios were significantly higher in patients with sarcoidosis compared to control subjects (all p values < 0.05).The novel repolarization parameters Tp-e interval, Tp-e/QT and Tp-e/QTc ratios are increased in patients with sarcoidosis without any cardiac symptoms. These parameters might be used as a marker for predicting the ventricular arrhythmias and sudden cardiac death in patients with sarcoidosis.
Adult, Male, Time Factors, Sarcoidosis, Heart Ventricles, Action Potentials, Patient Positioning, Electrocardiography, Sarcoidosis, Pulmonary, Heart Conduction System, Predictive Value of Tests, Risk Factors, Supine Position, Humans, Tpeak-Tend Interval, Retrospective Studies, Tp-E/Qt Ratio, Arrhythmias, Cardiac, Middle Aged, Prognosis, Electrocardiogram, Death, Sudden, Cardiac, Female
Adult, Male, Time Factors, Sarcoidosis, Heart Ventricles, Action Potentials, Patient Positioning, Electrocardiography, Sarcoidosis, Pulmonary, Heart Conduction System, Predictive Value of Tests, Risk Factors, Supine Position, Humans, Tpeak-Tend Interval, Retrospective Studies, Tp-E/Qt Ratio, Arrhythmias, Cardiac, Middle Aged, Prognosis, Electrocardiogram, Death, Sudden, Cardiac, Female
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