For the correct procedure of vein puncture--to collect blood specimens--it is necessary to keep strictly the rules of securing the safety of patient, the one who collects the specimen and also the specimen. The preparation of the patient for the vein puncture, the using of the correct method and vein, the appropriate time of doing this procedure, the using of the sufficient quantity of blood for every blood examination are included to the main elements for the success of the purpose of vein puncture. Another important element for the success of the above procedure is the comfortable and appropriate position of the patient, which gives the blood taker comfort in his work and keeps the patient free from undesirable events. The steps taken after this procedure can help: (a) keeping the vein in a good condition, (b) preventing undesirable events in the point of vein puncture, (c) sending the blood specimen safely to the laboratory, (d) safe disposal of the material used in the procedure. Undesirable events during the vein puncture should be faced immediately. In the newborn children blood specimen is collected from the finger with a different procedure. Also in isolated or mentally ill patients and those under radiation treatment the procedure is different. Those who collect and handle the blood specimens, nurses or laboratory technicians, do face important problems. For the prevention of harmful events special rules must be kept.