Synthesis and antiinflammatory/analgesic activities of N-heterocyclic carboxamides of thiopyrano-1,2-benzothiazine.
Copyright policy )Synthesis and antiinflammatory/analgesic activities of N-heterocyclic carboxamides of thiopyrano-1,2-benzothiazine.
We report the synthesis of N-heterocyclic carboxamides of 5-methyl-4-oxo-2,3,4,5-tetrahydrothiopyrano [3,2-c][1,2]benzothiazine 6,6-dioxide, their antiinflammatory and analgesic activities and the attempts to obtain a corresponding sulfoxidate series. Compounds (II c) and (II l) showed a good antiinflammatory activity which is comparable to that of piroxicam. No compound showed any significant analgesic activity.
- University of Perugia Italy
Male, Chemical Phenomena, Anti-Inflammatory Agents, Non-Steroidal, Thiazines, Rats, Inbred Strains, Sulfides, Rats, Chemistry, Piroxicam, Heterocyclic Compounds, Reaction Time, Animals, Oxidation-Reduction, Pyrans
Male, Chemical Phenomena, Anti-Inflammatory Agents, Non-Steroidal, Thiazines, Rats, Inbred Strains, Sulfides, Rats, Chemistry, Piroxicam, Heterocyclic Compounds, Reaction Time, Animals, Oxidation-Reduction, Pyrans
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