
Insulin dependent diabetes is an organ specific immunologic disease caused by pancreatic B cell destruction, mediated by T lymphocytes Present knowledge about insulin dependent diabetes immunogenetics and their relationship with the HLA system is reviewed, highlighting the polymorphism of the D area of that system and its connectors with diabetes. Possible therapeutic interventions in the autoimmune destructive process are discussed.
Major Histocompatibility Complex, Medicine (General), HLA-D Antigens, R5-920, Diabetes Mellitus, Type 1, R, Medicine, Humans, Autoimmunity, Genetic Predisposition to Disease, Diabetic Angiopathies
Major Histocompatibility Complex, Medicine (General), HLA-D Antigens, R5-920, Diabetes Mellitus, Type 1, R, Medicine, Humans, Autoimmunity, Genetic Predisposition to Disease, Diabetic Angiopathies
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