Stereoselectivity of the interaction of muscarinic antagonists with their receptors.
Copyright policy )Stereoselectivity of the interaction of muscarinic antagonists with their receptors.
The stereoselectivity of the interaction with muscarinic receptors of enantiomers of a series of chiral antagonists is receptor subtype dependent. There is no overall relationship between stereoselectivity and receptor affinity. Depending on the antagonist studied, receptor stereoselectivity may indeed reflect: (1) the weakening or loss of a single interaction involving one of the four groups bound to the asymmetric carbon; (2) steric hindrance preventing optimum interaction of the low affinity steroisomer with the receptor; and/or (3) the inversion of the relative positions of two moieties of the ligand with similar structural and electronic properties i.e. comparable affinities for the two corresponding subsites in the receptor.
info:eu-repo/semantics/published
SCOPUS: cp.j
- Université Libre de Bruxelles Belgium
Muscarinic -- drug effects, Parasympatholytics, Stereoisomerism, Parasympatholytics -- pharmacology, Sciences bio-médicales et agricoles, Receptors, Muscarinic, Receptors, Muscarinic -- drug effects, Receptors, Animals, Humans
Muscarinic -- drug effects, Parasympatholytics, Stereoisomerism, Parasympatholytics -- pharmacology, Sciences bio-médicales et agricoles, Receptors, Muscarinic, Receptors, Muscarinic -- drug effects, Receptors, Animals, Humans
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