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International Journal of Clinical and Experimental Medicine
Article . 2016
Data sources: Europe PubMed Central
Claim

Microsatellite instability of gastric cancer and precancerous lesions.

descriptionPublicationkeyboard_double_arrow_right Article 17 Feb 2016 English Journal:International journal of clinical and experimental medicine, volume 8 (issn: 1940-5901, Copyright policy )
Authors: Bing, Li; Hong-Yi, Liu; Shao-Hua, Guo; Peng, Sun; Fang-Ming, Gong; Bao-Qing, Jia;

pmid: 26885046

pmc: PMC4723891

Microsatellite instability of gastric cancer and precancerous lesions.

Abstract

To investigate whether microsatellite instability (MSI) of gastric cancer and precancerous lesions were existed and its effect.Laser microdissection was used. Gastric, intestinal metaplasia, dysplasia and normal mucosa were collected respectively. Five microsatellite loci were selected and MSI was detected by denaturing high-performance liquid chromatography.In the five microsatellite loci REF-positive phenotype, intestinal metaplasia MSI was 20.7%. Dysplasia MSI was 22.4%. Gastric MSI was 47.9%, and there was no MSI in normal gastric mucosa.MSI gradually increased from precancerous lesions to gastric cancer. The early detection of MSI may be a potential early warning indicator for early diagnosis of gastric cancer.

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 8
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Average
Average
Top 10%
gold
Related to Research communities
Cancer Research