Biceps tenodesis is a common procedure performed for tendinopathy of the long head of the biceps brachii (LHB). Indications include partial-thickness LHB tear, tendon subluxation with or without subscapularis tear, and failed conservative management of bicipital tenosynovitis. Biceps tenodesis may also be performed for superior labrum anterior to posterior tears. Evaluation of biceps stability is important in the treatment of LHB pathology. We advocate a technique of subpectoral biceps tenodesis. Interference screw fixation has demonstrated biomechanical superiority in laboratory models. If there are any concomitant operations, such as rotator cuff repair, the postoperative rehabilitation protocol may need to be adjusted. Overall, subpectoral biceps tenodesis with interference screw fixation has had excellent clinical outcomes and low complication rates.