In this paper, from the concept of acupoint compatibility, it is proposed that acupoint selection is a key factor to influence the compatibility of acupoint, and the nature of acupoint is closely related with the location and dominant meridian of acupoints. Acupoint selection according to the location and meridians is the basic method of acupoint compatibility, while acupoint selection based on the syndrome differentiation and the symptoms is the fundamental requirement of acupoint compatibility. Therefore, understanding the nature of acupoint, knowing the method of acupoint compatibility and selecting analogous acupoint that have identical or similar indications are the keys to improve the clinical efficacy.