Sarcoidosis: an alveolar macrophage disease?
Copyright policy )Sarcoidosis: an alveolar macrophage disease?
The Authors focus on new functions of alveolar macrophages (AM) from patients with active pulmonary sarcoidosis. They show that sarcoid AM present a candidacidal activity higher than normal controls, probably due to an enhanced phagocytic efficiency. Furthermore, after LPS stimulation cultured sarcoid AM secrete larger amount of interleukin 1 (IL-1) and of tumor necrosis factor (TNF) than normal controls. In conclusion, a new key role is emerging for sarcoid AM: not only an antigen-presenting cell, but a cell with a great primitive potential in modulating the inflammatory process.
- University of Perugia Italy
Phagocytosis, Sarcoidosis, Tumor Necrosis Factor-alpha, Macrophages, Candida albicans, Humans, Alveolar Macrophage, Bronchoalveolar Lavage Fluid, Interleukin-1
Phagocytosis, Sarcoidosis, Tumor Necrosis Factor-alpha, Macrophages, Candida albicans, Humans, Alveolar Macrophage, Bronchoalveolar Lavage Fluid, Interleukin-1
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