The biocompatibilities of two silicones ("Homburg" and "St. Wendel" silicone) and "Perspex CQ" (Titmus Eurocon Kontaktlinsen GmbH, Aschaffenburg) were tested in rabbits' eyes using the anterior chamber implantation test. Test criteria were iris folds, corneal opacification, fibrin flocks, and iris hyperemia. All the materials proved to be sufficiently biocompatible for use in the production of intraocular lenses. The two silicones appear to cause corneal opacification more often than "Perspex CQ". "Homburg" silicone only rarely seems to cause iris folds. There are no statistically significant differences in the biocompatibility of the tested materials. Clinical observations were in agreement with the test results.