This report of thirty-five resection/interposition arthroplasties of the wrist emphasizes the value of the human dermis in comparison to other materials as a mechanically reliable and simultaneously vital interposition. In up to 75% of cases of rheumatoid arthritis this technique is indicated when the flexion contracture of the wrist disturbs the balance of the tendons and when the compensation offered by neighbouring joints is insufficient. Out of 297 joints treated by corium interposition arthroplasty, thirty-five were performed on the wrist. Review after up to sixteen years shows eighteen good, fourteen satisfactory, and three unsatisfactory results.