Stamping-out of animals in case of infections diseases has to meet the requirements resulting from animal welfare, disease prevention, and practicability under conditions in practice. This is well qualified by application of electrical shock stunning with subsequent generation of ventricular fibrillation in cattle, swine and sheep. The scientific elements of the method, the procedure, and experiences in application of the method during the stamping-out of 340 cattle, 980 swine, 152 sheep and 18 goats are discussed in the paper.