Interleukin-12 and interleukin-23 inhibition in psoriatic arthritis.

Hanna J, Johnsson; Iain B, McInnes

Found an issue? Give us feedback

Clinical and Experim...arrow_drop_down

Clinical and Experimental Rheumatology

Article . 2015

Data sources: Europe PubMed Central

Interleukin-12 and interleukin-23 inhibition in psoriatic arthritis.

descriptionPublicationkeyboard_double_arrow_right Article 16 Dec 2015 English Journal:Clinical and experimental rheumatology, volume 33 (issn: 0392-856X,

Copyright policy )

Authors: Hanna J, Johnsson; Iain B, McInnes;

pmid: 26471946

Interleukin-12 and interleukin-23 inhibition in psoriatic arthritis.

- Summary
- Subjects
- Metrics

Abstract

The cytokines interleukin (IL)-12 and interleukin (IL)-23 have been implicated variously in the pathogenesis of psoriasis and psoriatic arthritis (PsA). By corollary, the IL-12/23 inhibitor, Ustekinumab has been developed as an approved therapeutic for the skin and musculoskeletal syndrome of psoriasis / PsA. This review describes briefly the role of IL-12 and IL-23 in the pathophysiology of psoriatic arthritis and evaluates trial data that support its clinical use in psoriasis and different manifestations of psoriatic arthritis. The next steps towards targeting this pathway also are discussed.

Related Organizations

University of Glasgow
United Kingdom

Keywords

Biological Products, Arthritis, Psoriatic, Remission Induction, Anti-Inflammatory Agents, Interleukin-12, Interleukin-23, Treatment Outcome, Animals, Humans, Molecular Targeted Therapy, Inflammation Mediators, Signal Transduction

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	16
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%