Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.
Copyright policy )Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.
To demonstrate the feasibility of using ultrashort echo-time MRI to quantify T1 changes in cortical bone due to heating.Variable flip-angle T1 mapping combined with 3D ultrashort echo-time imaging was used to measure T1 in cortical bone. A calibration experiment was performed to detect T1 changes with temperature in ex vivo cortical bone samples from a bovine femur. Ultrasound heating experiments were performed using an interstitial applicator in ex vivo bovine femur specimens, and heat-induced T1 changes were quantified.The calibration experiment demonstrated that T1 increases with temperature in cortical bone. We observed a linear relationship between temperature and T1 with a linear coefficient between 0.67 and 0.84 ms/°C over a range of 25-70°C. The ultrasound heating experiments showed increased T1 changes in the heated regions, and the relationship between the temperature changes and T1 changes was similar to that of the calibration.We demonstrated a temperature dependence of T1 in ex vivo cortical bone using a variable flip-angle ultrashort echo-time T1 mapping method.
- University of California, San Francisco United States
MR temperature mapping, cortical bone, Biomedical Engineering, 610, In Vitro Techniques, Sensitivity and Specificity, Imaging, Body Temperature, High-Energy Shock Waves, Heating, Engineering, Computer-Assisted, Imaging, Three-Dimensional, Clinical Research, Image Interpretation, Computer-Assisted, Animals, UTE imaging, Femur, Image Interpretation, Reproducibility of Results, T-1 mapping, T1 mapping, Magnetic Resonance Imaging, Nuclear Medicine & Medical Imaging, Thermography, Three-Dimensional, Women's Health, Biomedical Imaging, Feasibility Studies, Cattle, Biomedical engineering
MR temperature mapping, cortical bone, Biomedical Engineering, 610, In Vitro Techniques, Sensitivity and Specificity, Imaging, Body Temperature, High-Energy Shock Waves, Heating, Engineering, Computer-Assisted, Imaging, Three-Dimensional, Clinical Research, Image Interpretation, Computer-Assisted, Animals, UTE imaging, Femur, Image Interpretation, Reproducibility of Results, T-1 mapping, T1 mapping, Magnetic Resonance Imaging, Nuclear Medicine & Medical Imaging, Thermography, Three-Dimensional, Women's Health, Biomedical Imaging, Feasibility Studies, Cattle, Biomedical engineering
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