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Vojnosanitetski Pregled
Article . 1990
Data sources: Europe PubMed Central
Claim

[The stability of the oxime Hi-6 in eyedrops].

descriptionPublicationkeyboard_double_arrow_right Article 10 May 1990 Serbian Journal:Vojnosanitetski pregled, volume 46 (issn: 0042-8450, Copyright policy )
Authors: I, Macić; M, Antunović;

pmid: 2631420

[The stability of the oxime Hi-6 in eyedrops].

Abstract

The stability of an efficacious antidote in the treatment of organophosphorous poisoning--HI-6 has been examined in aqueous solutions of eye drops by accelerated stability tests. Disintegration kinetics has been examined at the increased temperatures and pH value of isotonic solution of 25 mg/ml concentration in ampules. First order hydrolysis is larger than in the known oximes: pralidoxime, obidoxime and other due to unfavourable physicochemical properties of HI-6. The period of 44 days which is necessary for reduction of exime concentration in eye drops for 10% at 25 degrees C is not enough for preservation of reliable solution and because of that it should be prepared whenever necessary.

Keywords

Drug Stability, Antidotes, Oximes, Pyridinium Compounds, Ophthalmic Solutions

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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Average
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