The Authors present a case of popliteal artery entrapment syndrome due to an anomalous insertion of medial head of the gastrocnemius muscle. The patient, a 47-year-old man, with calf claudication, was examined with Doppler velocimetry and angiography. He was successfully treated by surgical intervention. A medial approach to the popliteal artery was utilized and the section of anomalous head of gastrocnemius muscle and popliteal thromboendarterectomy were performed. The postoperative course was uncomplicated.