Fructus Ligustri Lucidi (FLL) inhibits the edema of hind Paw induced by injection of 1% carrageenin 0.1 ml, fresh egg 0.1 ml or 2.5% formaldehyde 0.1 ml in rats, and suppresses the increased vascular permeability induced by 0.7% acetic acid in mice and the proliferation of granuloma induced by cottonpellet in rats. The swelling of ear induced by xylene in mice and the content of prostaglandin E in inflammatory tissue of rats are also decreased by FLL. FLL increase the weight of adrenal in rats, but has no marked effect on the weight of thymus of rats.