[Study on pharmacokinetics of demethoxycurcumin phospholipid complex in rats].
Copyright policy )[Study on pharmacokinetics of demethoxycurcumin phospholipid complex in rats].
To study the pharmacokinetics of Demethoxycurcumin phospholipid complex in rats with oral administration.Drawing blood from the SD rats after oral administration Demethoxycurcumin phospholipid complex and free demethoxycurcumin. The blood concentration were determined by HPLC.The pharmacokinetics parameter of Demethoxycurcumin phos- pholipid complex were calculated and the results were as follows: AUC0-t (693. 306 ± 128. 55) µg/(L . h),1. 96-fold increase in the area under the plasma concentration versus time curve (AUC0-t) than that of free demethoxycurcumin, and AUC0-∞ (716. 174 ± 123. 18) µg/(L - h), 1. 93-fold increase than that of free demethoxycurcumin. Cmax (95. 044 ± 6. 95) µg/L, Tmax (0. 17 ± 0) h. Conclusion:Demethoxycurcumin phospholipid complex have higher bioavailability than free demethoxycurcumin,and their preparations bioequivalence are unqualified.
Curcumin, Administration, Oral, Biological Availability, Rats, Rats, Sprague-Dawley, Therapeutic Equivalency, Diarylheptanoids, Area Under Curve, Animals, Chromatography, High Pressure Liquid, Phospholipids
Curcumin, Administration, Oral, Biological Availability, Rats, Rats, Sprague-Dawley, Therapeutic Equivalency, Diarylheptanoids, Area Under Curve, Animals, Chromatography, High Pressure Liquid, Phospholipids
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