[(18)F]Fluorodeoxyglucose positron-emission tomography with computed tomography ((18)F-FDG-PET/CT) was assessed regarding its utility in prediction of outcomes after curative resection of colorectal cancer.Preoperative (18)F-FDG-PET/CT was performed in 325 patients with colorectal cancer. Maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic volume (MV), and total lesion glycolysis (TLG) were measured. Patients were divided into groups using cut-offs for overall survival (OS). (18)F-FDG-PET/CT parameters and other clinicopathological factors were investigated as prognostic factors.The 5-year OS rates in the low and high SUVmax, SUVmean, MV, and TLG groups were 91.4% and 87.0% (p=0.238), 90.8% and 88.2% (p=0.453), 91.7% and 83.8% (p=0.006), and 92.1% and 70.1% (p=0.001), respectively, indicating poorer outcomes in patients with high MV and TLG. In multivariate analysis, high TLG, age ≥65 years, rectal tumor location, and pN(+) were independent factors predicting a poor prognosis.TLG in (18)F-FDG-PET/CT is a prognostic parameter for colorectal cancer after curative resection.