[Radiation and combined treatment of anaplastic neuroepithelial neoplasms].

The data on 645 patients with anaplastic neuroepithelial tumors subjected to radiotherapy, irradiation with radiosensitizers (metronidazole) and chemoradiotherapy are presented. Total-differential brain irradiation was applied: 10-40 Gy on the whole brain and 10-20 Gy on the tumor bed. Fractionation depended on tumor radiosensitivity. The median survival time for anaplastic astrocytoma was 50 +/- 5.6 mos., oligodendroglioblastoma - 42 +/- 7.4 mos., ependymoblastoma - 61 +/- 8.2 mos. and glioblastoma - 22 +/- 1.5 mos. High-dose dynamic fractionation proved to be most effective in cases of glioblastoma. The outcome of glioblastoma was modified neither by radiosensitizers nor by cytotoxic agents.

Keywords

Radiation-Sensitizing Agents, Brain Neoplasms, Oligodendroglioma, Antineoplastic Agents, Electrons, Radiotherapy Dosage, Glioma, Astrocytoma, Combined Modality Therapy, Ependymoma, Humans, Neuroectodermal Tumors, Primitive, Peripheral, Cobalt Radioisotopes

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