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Caveolin-1, breast cancer and ionizing radiation.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2015 Italy English Publisher:International Institute of Anticancer ResearchJournal:Cancer genomics & proteomics, volume 12 (issn: 1790-6245,

Authors: Pucci M; Bravatà V; Forte GI; Cammarata FP; Messa C; Gilardi MC; Minafra L;

pmid: 25977173

handle: 20.500.14243/295747 , 10281/114853 , 10447/233420

Caveolin-1, breast cancer and ionizing radiation.

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Abstract

Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contrasting dual functions as an oncogene and as a tumor suppressor. In addition, we report on how CAV1 may contribute to tumor cell response to ionizing radiation treatment. Finally, new roles of CAV1 in BC both on epithelium and stroma may be useful as prognostic indicators for patient treatment and help clinicians in the selection of the best personalized therapy.

Country

Italy

Related Organizations

University of Milano-Bicocca
Italy
University of Palermo
Italy
Institute of Molecular Bioimaging and Physiology
Italy
National Research Council
Italy

Keywords

Ionizing, Caveolin 1, review, Breast Neoplasms, Cell Transformation, breast cancer, Radiation, Ionizing, Biomarker; Breast cancer; CAV1; Ionizing radiation; Review;, Biomarkers, Tumor, Animals, Humans, Molecular Targeted Therapy, Neoplastic, Tumor, Radiation, Epidermal Growth Factor, Radiotherapy, CAV1; biomarker; breast cancer; ionizing radiation; review; Animals; Biomarkers, Tumor; Breast Neoplasms; Caveolin 1; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Radiotherapy; Receptor, Epidermal Growth Factor; Radiation, Ionizing, ErbB Receptors, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, Gene Expression Regulation, CAV1, biomarker, Female, ionizing radiation, Biomarkers, Receptor

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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%