Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance.
Copyright policy )Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance.
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP).Isolates from two major urban centres--Paris (101 strains) and Shanghai (171 strains)--were investigated for the association of pncA mutations with resistance to drugs other than PZA.The proportion of pncA mutations found in INH-monoresistant strains was not increased.pncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.
- Chinese Academy of Sciences China (People's Republic of)
- Fudan University China (People's Republic of)
- Institut Pasteur France
- National Public Health Laboratory Nepal
- Instituto Venezolano de Investigaciones Científicas Venezuela
DNA, Bacterial, China, Paris, pyrazinamide, drug resistance, Genotype, Extensively Drug-Resistant Tuberculosis, DNA Mutational Analysis, Antitubercular Agents, Microbial Sensitivity Tests, Mycobacterium tuberculosis, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Pyrazinamide, Amidohydrolases, [SDV] Life Sciences [q-bio], Phenotype, tuberculosis, Gene Frequency, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Drug Resistance, Multiple, Bacterial, Mutation, Tuberculosis, Multidrug-Resistant, Humans, Rifampin, Fluoroquinolones
DNA, Bacterial, China, Paris, pyrazinamide, drug resistance, Genotype, Extensively Drug-Resistant Tuberculosis, DNA Mutational Analysis, Antitubercular Agents, Microbial Sensitivity Tests, Mycobacterium tuberculosis, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Pyrazinamide, Amidohydrolases, [SDV] Life Sciences [q-bio], Phenotype, tuberculosis, Gene Frequency, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Drug Resistance, Multiple, Bacterial, Mutation, Tuberculosis, Multidrug-Resistant, Humans, Rifampin, Fluoroquinolones
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